Co- and multimorbidity patterns in an unselected Norwegian population: cross-sectional analysis based on the HUNT Study and theoretical reflections concerning basic medical models
Abstract
Rationale and aims: Accumulating evidence shows that diseases tend to cluster in diseased individuals, so-called multimorbidity. The aim of this study was to analyze multimorbidity patterns, empirically and theoretically, to better understand the phenomenon.
Population and methods: The Norwegian population-based Nord-Trøndelag Health Study HUNT 3 (2006-8), with 47,959 individuals aged 20-79 years. A total of 21 relevant, longstanding diseases/malfunctions were eligible for counting in each participant. Multimorbidity was defined as two or more chronic conditions.
Results: Multimorbidity was found in 18% of individuals aged 20 years. The prevalence increased with age in both sexes. The overall age-standardized prevalence was 42% (39% for men, 46% for women). ‘Musculoskeletal disorders’ was the disease-group most frequently associated with multimorbidity. Three conditions, strategically selected to represent different diagnostic domains according to biomedical tradition; gastro-esophageal reflux, thyroid disease and dental problems, were all associated with both mental and somatic comorbid conditions.
Conclusions and implications: Multimorbidity appears to be prevalent in both genders and across age-groups, even in the affluent and relatively equitable Norwegian society. The disease clusters typically transcend biomedicine’s traditional demarcations between mental and somatic diseases and between diagnostic categories within each of these domains. A new theoretical approach to disease development and recovery is warranted, in order to adequately tackle ‘the challenge of multimorbidity’, both empirically and clinically. We think the concept allostatic load can be systematically developed to “capture” the interrelatedness of biography and biology and to address the fundamental significance of “that, which gains” versus “that, which drains” any given human being.Keywords
Full Text:
PDFReferences
Mangin, D., Heath, I. & Jamoulle, M. (2012). Beyond diagnosis: rising to the multimorbidity challenge. British Medical Journal 344, 3526.
Parekh, A.K. & Barton, M.B. (2010). The challenge of multiple comorbidity for the US health care system. Journal of the American Medical Association 303 (13) 1303-1304.
Petursson, H. (2012). The validity and relevance of international cardiovascular disease prevention guidelines for general practice. PhD Thesis. Department of Public Health and General Practice. Norwegian University of Science and Technology. http://ntnu.diva-portal.org/smash/record.jsf?pid=diva2:525477.
Starfield, B. (2011). The hidden inequity in health care. International Journal for Equity in Health 10 (1) 15.
Fuller, J. (2013). Rationality and the generalization of randomized controlled trial evidence. Journal of Evaluation in Clinical Practice doi:10.1111/jep.12021.
Van den Akker, M., Buntinx, F., Metsemakers, J.F., Roos, S. & Knottnerus, J.A. (1998). Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. Journal of Clinical Epidemiology 51 (5) 367-375.
Starfield, B. (2003). Comorbidity: Implications for the Importance of Primary Care in “Case” Management. Annals of Family Medicine 1 (1) 8-14.
Valderas, J.M., Sibbald, B. & Salisbury, C. (2009). Defining comorbidity: Implications for understanding health and health services. Annals of Family Medicine 7 (4) 357-363.
Mercer, S.W., Smith, S.M., Wyke, S., O’Dowd, T. & Watt, G.C.M. (2009). Multimorbidity in primary care: developing the research agenda. Family Practice 26 (2) 79-80.
Starfield, B. & Kinder, K. (2011). Multimorbidity and its measurement. Health Policy 103 (1) 3-8.
Stange, K.C. (2012). In this issue: Challenges of managing simplifying care for complex patients. Annals of Family Medicine 10 (1) 2-3.
The International Research Community on Multimorbidity (IRCMo)‘s blog on multimorbidity [website]. Available at: https://pages.usherbrooke.ca/crmcspl-blog/ (accessed 2 April 2013)
Salisbury, C., Johnson, L., Purdy, S., Valderas, J.M. & Montgomery, A.A. (2011). Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study. British Journal of General Practice 61 (582) 12-21.
Hartz, A. & James, P.A. (2006). A systematic review of studies comparing myocardial infarction mortality for generalists and specialists: lessons for research and health policy. Journal of the American Board of Family Medicine 19 (3) 291-302.
Vikum, E., Krokstad, S. & Westin, S. (2012). Socioeconomic inequalities in health care utilisation in Norway: the population-based HUNT3 survey. International Journal for Equity in Health 11 (1) 48.
Fortin, M., Hudon, C., Haggerty, J., van den Akker, M. & Almirall, J. (2010). Prevalence estimates of multimorbidity: a comparative study of two sources. BMC Health Services Research 10, 111-117.
Fortin, M., Stewart, M., Poitras, M. & Maddocks, H. (2012). A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Annals of Family Medicine 10 (2) 142-151.
Taylor, A.W., Price, K., Gill, T.K., Adams, R., Pilkington, R., Carrangis, N., Shi, Z. & Wilson, D. (2012). Multimorbidity - not just an older person’s issue. Results from an Australian biomedical study. BMC Public Health 10 (1) 718.
Barnett, K., Mercer, S.W., Norbury, M., Watt, G., Wyke, S. & Guthrie, B. (2012). Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 380 (9836) 37-43.
McIntyre, R., Soczynska, J., Konarski, J., Woldeyohannes, H., Law, C., Miranda, A., Fulgosi, D. & Kennedy, S.H. (2007). Should depressive syndromes be reclassified as “Metabolic Syndrome Type II”? Annals of Clinical Psychiatry 19 (4) 257-264.
Wolkowitz, O.M., Reus, V.I. & Mellon, S.H. (2011). Of sound mind and body: depression, disease, and accelerated aging. Dialogues in Clinical Neuroscience 13, 25-39.
Stuart, M.J. & Baune, B.T. (2012). Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neuroscience and Biobehavioral Reviews 36 (1) 658-676.
Prados-Torres, A., Poblador-Plou, B., Calderón-Larrañaga, A., Gimeno-Feliu, L.A., González-Rubio, F., Poncel-Falcó, A., Sicras-Mainar, A. & Alcalá-Nalvaiz, J.T. (2012). Multimorbidity patterns in primary care: interactions among chronic diseases using factor analysis. PloS One 7 (2) 32190.
Bousquet, J., Anto, J.M., Sterk, P.J., et al. (2011). Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Medicine 3 (7) 43.
Marmot, M., Shipley, M., Brunner, E. & Hemingway, H. (2001). Relative contribution of early life and adult socioeconomic factors to adult morbidity in the Whitehall II study. Journal of Epidemiology and Community Health 55 (5) 301-307.
Seeman, T., Epel, E., Gruenewald, T., Karlamangla, A. & McEwen, B.S. (2010). Socio-economic differentials in peripheral biology: cumulative allostatic load. Annals of the New York Academy of Sciences 1186, 223-239.
Tucker-Seeley, R.D., Li, Y., Sorensen, G. & Subramanian, S.V. (2011). Lifecourse socioeconomic circumstances and multimorbidity among older adults. BMC Public Health 11, 313.
Schäfer, I., Hansen, H., Schön, G., Höfels, S., Altiner, A., Dahlhaus, A., Gensichen, J., Riedel-Heller, S., Weyerer, S., Blank, W.A., König, H.H., von dem Knesebeck, O., Wegscheider, K., Scherer, M., van den Bussche, H. & Wiese, B. (2012). The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study. BMC Health Services Research 12 (1) 89.
Mercer, S.W., Guthrie, B., Furler, J., Watt, G.C.M. & Hart, J.T. (2012). Multimorbidity and the inverse care law in primary care. British Medical Journal 344, e4152-e4152.
Elovainio, M., Ferrie, J.E., Singh-Manoux, A., Gimeno, D., De Vogli, R., Shipley, M., Vahtera, J., Brunner, E., Marmot M.G. & Kivimäki, M. (2010). Organisational justice and markers of inflammation: the Whitehall II study. Occupational and Environmental Medicine 67 (2) 78-83.
Marmot, M. & Brunner, E. (2005). Cohort Profile: the Whitehall II study. International Journal of Epidemiology 34 (2) 251-256.
Westerlund, H., Gustafsson, P.E., Theorell, T., Janlert, U. & Hammarström, A. (2012). Social adversity in adolescence increases the physiological vulnerability to job strain in adulthood: a prospective population-based study. PloS One 7 (4) e35967.
Barnes, P.J. (2010). Chronic obstructive pulmonary disease: effects beyond the lungs. PLoS Medicine 7 (3) e1000220.
Thayer, J.F., Yamamoto, S.S. & Brosschot, J.F. (2010). The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. International Journal of Cardiology 141 (2) 122-131.
McEwen, B.S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine 338 (3) 171-179.
McEwen, B.S. (2012). Brain on stress: How the social environment gets under the skin. Proceedings of the National Academy of Sciences of the United States of America 109 (Supplement 2) 17180-17185.
Felitti, V.J., Anda, R.F., Nordenberg, D., Williamson, D.F., Spitz, A.M., Edwards, V., Koss, M.P. & Marks, J.S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine 14 (4) 245-258.
The Adverse Childhood Experiences Study homepage [website]. Available at: www.cdc.gov/ace/ (accessed 2 April 2013).
Anda, R.F., Felitti, V.J., Bremner, J.D., Walker, J.D., Whitfield, C., Perry, B.D., Dube, S.R. & Giles, W.H. (2006). The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience 256 (3) 174-186.
Shonkoff, J.P., Boyce, W.T. & McEwen, B.S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. Journal of the American Medical Association 301 (21) 2252-2259.
Danese, A. & McEwen, B.S. (2012). Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior 106 (1) 29-39.
Shalev, I., Moffitt, T.E., Sugden, K., Williams, B., Houts, R.M., Danese, A., Mill, J., Arseneault, L. & Caspi, A. (2013). Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Molecular Psychiatry 18 (5) 576-581.
Kirkengen, A.L., Mjølstad, B.P., Getz, L., Ulvestad, E. & Hetlevik, I. (2013). Can person-free medical knowledge inform person-centered medical practice?. European Journal for Person Centered Healthcare X (x) xx-xx
Smith, S.M., Soubhi, H., Fortin, M., Hudon, C. & O’Dowd, T. (2012). Managing patients with multimorbidity: systematic review of interventions in primary care and community settings. British Medical Journal 345, e5205.
Krieger, N. (2005). Embodiment: a conceptual glossary for epidemiology. Journal of Epidemiology and Community Health 59 (5) 350-355.
Krokstad, S., Langhammer, A., Hveem, K., Holmen, T., Midthjell, K., Stene, T., Bratberg, G., Heggland, J. & Holmen, J. (2012). Cohort Profile: The HUNT Study, Norway. International Journal of Epidemiology PMID:22879362 [Epub ahead of print].
Langhammer, A., Krokstad, S., Romundstad, P., Heggland, J. & Holmen, J. (2012). The HUNT study: participation is associated with survival and depends on socioeconomic status, diseases and symptoms. BMC Medical Research Methodology 12 (1) 143.
NICE Clinical Guidelines. (2011). [website]. Clinical management of primary hypertension in adults. Available at: http://www.nice.org.uk/nicemedia/live/13561/56008/56008.pdf (accessed 2 April 2013)
Petursson, H., Getz, L., Sigurdsson, J. A. & Hetlevik, I. (2009). Can individuals with a significant risk for cardiovascular disease be adequately identified by combination of several risk factors? Modelling study based on the Norwegian HUNT 2 population. Journal of Evaluation in Clinical Practice 15 (1) 103-109.
Bailey, R.L., Ledikwe, J.H., Smiciklas-Wright, H., Mitchell, D.C. & Jensen, G.L. (2004) Persistent oral health problems associated with comorbidity and impaired diet quality in older adults. Journal of the American Dietetic Association 104 (8) 1273-1276.
Cooper, D.S. & Biondi, B. (2012). Subclinical thyroid disease. Lancet 379 (9821) 1142-1154.
Moraes-Filho, J.P.P., Navarro-Rodriguez, T., Eisig, J.N., Barbuti, R.C., Chinzon, D. & Quigley, E.M.M. (2009). Comorbidities are frequent in patients with gastroesophageal reflux disease in a tertiary health care hospital. Clinics 64 (8) 785-790.
Hudon, C. & Fortin, M. (2008). Chronic musculoskeletal conditions and comorbidities in primary care settings. Canadian Family Physician 54, 74-75.
Breckan, R.K., Asfeldt, A.M., Straume, B., Florholmen, J. & Paulssen, E.J. (2012). Prevalence, comorbidity, and risk factors for functional bowel symptoms: a population-based survey in Northern Norway. Scandinavian Journal of Gastroenterology 47 (11) 1274-1282.
Rodondi, N., den Elzen, W.P.J., Bauer, D.C., Cappola, A.R., Razvi, S., Walsh, J.P., Asvold, B.O., Iervasi, G., Imaizumi, M., Collet, T.H., Brember, A., Maisonneuve, P., Sqarbi, J.A., Khaw, K.T., Vanderpump, M.P., Newman, A.B., Cornuz, J., Franklyn, J.A., Westendorp, R.G., Vittinghoff, E., Gussekloo, J. & Thyroid Studies Collaboration. (2010). Subclinical hypothyroidism and the risk of coronary heart disease and mortality. Journal of the American Medical Association 304 (12) 1365-1374.
Berger, M.B., Damico, N.J., Menees, S.B., Fenner, D.E. & Haefner, H.K. (2012). Rates of self-reported urinary, gastrointestinal, and pain comorbidities in women with vulvar Llichen sclerosus. Journal of Lower Genital Tract Disease 16 (3) 285-289.
Sabbah, W., Watt, R.G., Sheiham, A. & Tsakos, G. (2008). Effects of allostatic load on the social gradient in ischaemic heart disease and periodontal disease: evidence from the Third National Health and Nutrition Examination Survey. Journal of Epidemiology and Community Health 62 (5) 415-420.
Boyce, W.T., den Besten, P.K., Stamperdahl, J., Zhan, L., Jiang, Y., Adler, N.E. & Featherstone, J.D. (2010). Social inequalities in childhood dental caries: the convergent roles of stress, bacteria and disadvantage. Social Science & Medicine 71 (9) 1644-1652.
Gullick, N.J. & Scott, D.L. (2011). Co-morbidities in established rheumatoid arthritis. Best Practice & Research Clinical Rheumatology 25 (4) 469-483.
Lalla, E. & Papapanou, P.N. (2011). Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nature Reviews Endocrinology 7, 738-748.
Eriksen, T.E., Kirkengen, A.L. & Vetlesen, A.J. (2012). The medically unexplained revisited. Medicine, Health Care and Philosophy [Epub ahead of print].
Miles, A. & Mezzich, J.E. (2011). The care of the patient and the soul of the clinic: person-centered medicine as an emergent model of modern clinical practice. International Journal of Person Centered Medicine 1 (2) 207-222.
Miles, A. (2012). Moving from a reductive anatomico-pathological medicine to an authentically anthropocentric model of healthcare: current transitions in epidemiology and epistemology and the ongoing development of person-centered clinical practice. International Journal of Person Centered Medicine 2 (4) 615-621.
Sterling, P. & Eyer, J. (1988). Allostasis: a new paradigm to explain arousal pathology. In: Handbook of Life Stress, Cognition and Health. (Fisher, S. & Reason, J., eds.). Chichester: Wiley.
Gersten, O. (2008). The path traveled and the path ahead for the allostatic framework: A rejoinder on the framework’s importance and the need for further work related to theory, data, and measurement. Social Science & Medicine 66 (3) 531-535.
Gersten, O. (2008). Neuroendocrine biomarkers, social relations, and the cumulative costs of stress in Taiwan. Social Science & Medicine 66 (3) 507-519.
Loucks, E.B., Juster, R.P. & Pruessner, J.C. (2008). Neuroendocrine biomarkers, allostatic load, and the challenge of measurement: A commentary on Gersten. Social Science & Medicine 66 (3) 525-530.
Gruenewald, T.L., Seeman, T.E., Ryff, C.D., Karlamangla, A.S. & Singer, B.H. (2006). Combinations of biomarkers predictive of later life mortality. Proceedings of the National Academy of Sciences of the United States of America 103 (38) 14158-14163.
Gruenewald, T.L., Karlamangla, A.S., Hu, P., Stein-Merkin, S., Crandall, C., Koretz, B. & Seeman, T.E. (2012). History of socioeconomic disadvantage and allostatic load in later life. Social Science & Medicine 74 (1) 75-83.
Mattei, J., Demissie, S., Falcon, L.M., Ordovas, J.M. & Tucker, K. (2010). Allostatic load is associated with Chronic conditions in the Boston Puerto Rican Health Study. Social Science & Medicine 70 (12) 1988-1996.
Seeman, T., Gruenewald, T., Karlamangla, A., Sidney, S., Liu, K., McEwen, B.S. & Schwartz, J. (2010). Modeling multisystem biological risk in young adults: The Coronary Artery Risk Development in Young Adults Study. American Journal of Human Biology 22 (4) 463-472.
Peters, A. & McEwen, B.S. (2012). Introduction for the allostatic load special issue. Physiology & Behavior 106 (1) 1-4.
Tomiyama, A.J., O´Donovan, A., Lin, J., Puterman, E., Lazaro, A., Chan, J., Dhabhar, F.S., Wolkowitz, O., Kirschbaum, C., Blackburn, E. & Epel, E. (2012). Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiology & Behavior 106 (1) 40-45.
Karatsoreos, I.N. & McEwen, B.S. (2011). Psychobiological allostasis: resistance, resilience and vulnerability. Trends in Cognitive Sciences 15 (12) 576-584.
McEwen, B.S. (2006). Protective and damaging effects of stress mediators: central role of the brain. Dialogues in Clinical Neuroscience 8 (4) 367-381.
Tremaroli, V. & Bäckhed, F. (2012). Functional interactions between the gut microbiota and host metabolism. Nature 489 (7415) 242-249.
Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E. & Savignac, H.M. (2011). Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. PNAS 108 (38) 16050-16055.
Kirkengen, A.L. & Thornquist, E. (2012). The lived body as a medical topic: an argument for an ethically informed epistemology. Journal of Evaluation in Clinical Practice 18 (5) 1095-10101.
McEwen, B.S., Eiland, L., Hunter, R.G. & Miller, M.M. (2012). Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 62 (1) 3-12.
Szyf, M. & Bick, J. (2012). DNA methylation: A mechanism for embedding early life experiences in the genome. Child Development 84 (1) 49-57.
Bavelier, D., Levi, D., Li, R., Dan, Y. & Hensch, T. (2010). Removing brakes on adult brain plasticity: from molecular to behavioral interventions. Journal of Neuroscience 30 (45) 14964-14971.
Obradovic, J. (2012). How can the study of physiological reactivity contribute to our understanding of adversity and resilience processes in development? Development and Psychopathology 24 (2) 371-387.
Seeman, T., Glei, D., Goldman, N., Weinstein, M., Singer, B. & Lin, Y-H. (2004). Social relationships and allostatic load in Taiwanese elderly and near elderly. Social Science & Medicine 59 (11) 2245-2257.
Kirkengen, A.L. (2010). The Lived Experience of Violation: How Abused Children Become Unhealthy Adults. Bucharest: Zeta Books.
Getz, L., Kirkengen, A.L. & Ulvestad, E. (2011). The human biology - saturated with experience. Tidsskrift for Den Norske Legeforening 131 (7) 683-687.
Needham, B.L., Fernandez, J.R., Lin, J., Epel, E.S. & Blackburn, E.H. (2012). Socioeconomic status and cell aging in children. Social Science & Medicine 74 (12) 1948-1951.
Blackburn, E.H. & Epel, E.S. (2012). Telomeres and adversity: Too toxic to ignore. Nature 490 (7419) 169-171.
Miles, A. (2012). Person-centered medicine – at the intersection of science, ethics and humanism, International Journal of Person Centered Medicine 2 (3) 329-333.
Bayliss, E.A., Ellis, J.L. & Steiner, J.F. (2005). Subjective assessments of comorbidity correlate with quality of life health outcomes: Initial validation of a comorbidity assessment instrument. Health and Quality of Life Outcomes 3, 51.
Starfield, B. (2011). Is patient-centered care the same as person-focused care? The Permanente Journal 15 (2) 63-69.
McEwen, B.S. & Getz, L. (2012). Lifetime experiences, the brain and personalized medicine: An integrative perspective. Metabolism: Clinical and Experimental 62 (Supplement 1) S20-26.
Sturmberg, J.P. (2012). Caring for people with chronic disease: is “muddling through” the best way to handle the multiple complexities? Journal of Evaluation in Clinical Practice 18 (6) 1220-1225.
Gurthrie, B., Payne, K., Alderson, P., McMurdo, M.E.T. & Mercer, S.W. (2012). Adapting clinical guidelines to take account of multimorbidity. British Medical Journal 345, 22-24.
Tonelli, M.R. (2012). Compellingness: assessing the practical relevance of clinical research results. Journal of Evaluation in Clinical Practice 18 (5) 962-967.
Klinkman, M. & van Weel, C. (2011). Prospects for person-centred diagnosis in general medicine. Journal of Evaluation in Clinical Practice 17 (2) 365-370.
DOI: http://dx.doi.org/10.5750/ejpch.v2i3.734
Refbacks
- There are currently no refbacks.